Difference between sedating and non sedating antihistamines Totally free no register instant home cams
receptor antagonists (antihistamines) penetrate the brain poorly, allowing the use of doses large enough to counteract allergic processes in peripheral tissues without important central effects.
The antihistamines reviewed here are acrivastine, astemizole, cetirizine, ebastine, fexofenadine, loratadine, mizolastine, and terfenadine.
Thus the 'non-sedating' title of the 2nd generation antihistamines refers to a low tendency to diminish CNS arousal when taken in therapeutic doses.
It is wise to restrict or avoid using antihistamines (astemizole, terfenadine) that can cause cardiac dysrhythmias, because even severe cardiotoxicity can occur in certain pharmacokinetic drug-drug interactions.The odds ratios for the incidence of sedation were 0.63 for fexofenadine, 2.79 for acrivastine and 3.53 for cetirizine compared with loratadine.